Dogs can experience anxiety, stress, depression, and other symptoms from time to time. Dogs can also be afraid of thunderstorms or travel phobias. These conditions can harm a dog’s health. Moreover, these conditions can be treated with Trazodone. This drug can cause severe side effects if it is not used correctly.

Trazodone, a common antidepressant, is used by humans and dogs. If you are a dog owner and you wondering if it is safe to use on dogs? Can Trazodone cause death in dogs? And even, Can kill a dog? In this article, you will learn anything you need to know about Trazodone.



What is Trazodone?

Trazodone belongs to the antidepressant category. The drug works by interfacing with certain serotonin receptors and inhibiting their activity in dogs’ brains. Dogs will experience fewer symptoms of depression and anxiety.

The tablet is usually marked in the middle, so you can easily cut it in half. These tablets can be either 50, 100, or 150 mg in size. They are immediate- or extended-release. Sometimes, the drug might be available in liquid or capsule form. However, these are very rare.

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Can Trazodone kill a dog?

Although Trazodone doesn’t pose a danger to dogs, high doses can adversely affect them. It is not known what the lethal dose (LD50) of Trazodone for dogs is. Seizures have been reported in dogs at 35 mg per pound.

To avoid accidental swallowing, your dog must keep your medication out of reach. If your dog is a family member, you should have a plan for administering the medication. To avoid any mix-ups, only one family member should administer the drug to the dog.



What are the side effects of Trazodone for dogs?

Dogs are generally safe with Trazodone. However, It can cause sedation in dogs, and it is not likely to cause drowsiness or lethargy. Some dogs may also experience side effects such as:

  • Panting
  • Diarrhea
  • Increased aggression
  • Vomiting
  • Appetite changes
  • Anxiety has increased
  • Priapism is a typical behavior in males.
  • Incoordination
  • Seizures

These symptoms usually disappear within a few days. If they continue or become severe, you should seek professional assistance.

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Trazodone and Serotonin Syndrome

Your dog might experience side effects such as serotonin Syndrome. This side effect is uncommon, however.

Serotonin syndrome is when a dog experiences vomiting, breathing problems, seizures, dizziness, diarrhea, and other symptoms. Stop giving your dog medication if you notice any symptoms of serotonin syndrome. Get professional help immediately to prevent further complications. The dosage of dog Trazodone varies from 1 to 3. daily. The maximum daily dose is 6.4mg per lb. The maximum daily dose is 6.4 mg. You should give the medication at intervals of eight hours to dogs who are on it. The dosage of Trazodone for dogs varies depending on many factors.


When deciding on the dosage, veterinarians will consider your dog’s weight. A heavier dog will generally receive a higher dose than a lighter one.

Other Medications

The dosage will also be affected if your dog is taking any medications. If your dog is on medication for fungal diseases, the vet may lower the dosage of Trazodone. Inform your vet about your pet’s current medical condition and any medication he is currently taking. They will be able to determine the correct dosage and prevent any complications.



Behavioral Problems

The dosage of Trazodone for dogs will also depend on your pet’s behavior. Vets will recommend a higher dose for dogs suffering from persistent behavioral disorders. The vet might recommend that your dog take the medication daily, depending on their condition.

A vet usually starts a dog on trazodone medication at a lower dose and then increases it as needed. Your vet can provide further guidance if your pet needs more drug.

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What happens if my dog is given a Trazodone overdose?

To avoid an overdose of Trazodone, you should always follow your veterinarian’s instructions. These are some of the signs that can indicate a excess dosage:

  • A decreased heart rate
  • Seizures
  • Tremors
  • Balance loss
  • Disorientation
  • An increase in blood pressure
  • Lower blood pressure
  • Coma




Most dogs tolerate Trazodone well. However, there may be side effects that could cause serious problems in your dog’s health. Your vet may recommend Trazodone to your dog. There are very few health risks. If your dog is on medication, keep them under close observation and notify your vet immediately if they develop symptoms.


I’m a long-time animal lover and owner of two dogs and three cats. I grew up on a farm where we had all sorts of animals, from cows and horses to pigs and chickens. My love for animals led me to pursue a career in writing about them. I have been a pet care writer for over 5 years and have extensive knowledge of animal care, health, and behavior.

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